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Kang YG, Jeong JY, Lee TH, Lee HS, Shin JW. Synergistic Integration of Mesenchymal Stem Cells and Hydrostatic Pressure in the Expansion and Maintenance of Human Hematopoietic/Progenitor Cells. Stem cells Int. 2018; 2018:4527929.

Kang YG, Wei J, Shin JW, Wu YR, Su J, Park YS, Shin J. Enhanced biocompatibility and osteogenic potential of mesoporous magnesium silicate/polycaprolactone/wheat protein composite scaffolds. Int J Nanomedicine. 2018, 13:1107-1117.

Wu YR, Choi HJ, Kang YG, Kim JK, Shin JW. In vitro study on anti-inflammatory effects of epigallocatechin-3-gallate-loaded nano- and microscale particles. Int J Nanomedicine. 2017 Sep;22(12):7007-13.

Wu YR, Kang YG, Shin JW, Kim MJ, Shin JW. Mechanical stimuli modulate intracellular calcium oscillations: a pathological model without chemical cues. Biotechnol Lett. 2017 Aug;39(8):1121-1127.

Park SH, Park SA, Kang YG, Shin JW, Park YS, Gu SR, Wu YR, Wei J, Shin JW. PCL/β-TCP composite scaffolds exhibit positive osteogenic differentiation with mechanical stimulation. TERM. 2017 Aug;14(4):349-858.

Kim YM, Kang YG, Park SH, Han MK, Kim JH, Shin JW, Shin JW. Effects of mechanical stimulation on the reprogramming of somatic cells into human-induced pluripotent stem cells. Stem Cell Res Ther. 2017 Jun 8;8(1):139.

Shin JW, Wu YR, Kang YG, Kim JK, Choi HJ, Shin JW. The effects of epigallocatechin-3-gallate and mechanical stimulation on osteogenic differentiation of human mesenchymal stem cells: individual or synergistic effects. TERM. 2017 June;14(3):307-15.

Wu Z, Li Q, Pan Y, Yao Y, Tang S, Su J, Shin JW, Wei J, Zhao J. Nanoporosity improved water absorption, in vitro degradability, mineralization, osteoblast responses and drug release of poly(butylene succinate)-based composite scaffolds containing nanoporous magnesium silicate compared with magnesium silicate. Int J Nanomedicine. 2017 May 11;12:3637-3651.

Cao L, Weng W, Chen X, Zhang J, Zhou Q, Cui J, Zhao Y, Shin JW, Su J. Promotion of in vivo degradability, vascularization and osteogenesis of calcium sulfate-based bone cements containing nanoporous lithium doping magnesium silicate. Int J Nanomedicine. 2017 Feb 17;12:1341-1352.

Gu SR, Kang YG, Shin JW, Shin JW. Simultaneous engagement of mechanical stretching and surface pattern promotes cardiomyogenic differentiation of human mesenchymal stem cells. J Biosci Bioeng. 2017 Feb;123(2):252-258.

L Cao, W Weng, X Chen, J Zhang, Q Zhou, J Cui, L Wang, JW Shin, J Su. Effects of mesoporous calcium magnesium silicate on setting time, compressive strength, apatite formation, degradability and cell behavior to magnesium phosphate based bone cements. RSC Advance. 2017 Jan;7:870-879.

Ban HY, Shin JW, Chun SI, Kang YG, Wu YR, Kim JE, Lee EJ, Kim MJ, Mun CW, Shin JW. Distinguishing tendon and ligament fibroblasts based on 1H nuclear magnetic resonance spectroscopy. TERM. 2016 Dec;13(6):677-83.

Shin JW, Park SH, Kang YG, Wu Y, Choi HJ, Shin JW. Changes, and the Relevance Thereof, in Mitochondrial Morphology during Differentiation into Endothelial Cells. PLoS One. 2016 Aug 12;11(8):e0161015.

Hou J, Fan D, Zhao L, Yu B, Su J, Wei J, Shin JW. Degradability, cytocompatibility, and osteogenesis of porous scaffolds of nanobredigite and PCL-PEG-PCL composite. Int J Nanomedicine. 2016 Jul 28;11:3545-55.

Kim DH, Heo SJ, Kang YG, Shin JW, Park SH, Shin JW. Shear stress and circumferential stretch by pulsatile flow direct vascular endothelial lineage commitment of mesenchymal stem cells in engineered blood vessels. J Mater Sci Mater Med. 2016 Mar;27(3):60.

Qian J, Ma J, Su J, Yan Y, Li H, Shin JW, Wei J, Zhao L. PHBV-based ternary composite by intermixing of magnesium calcium phosphate nanoparticles and zein: in vitro bioactivity, degradability and cytocompatibility. European Polymer Journal. 2016 Feb;75:291-302.

Kang YG, Shin JW, Park SH, Kim YM, Gu SR, Wu Y, Ban HY, Shin JW. A three-dimensional hierarchical scaffold fabricated by a combined rapid prototyping technique and electrospinning process to expand hematopoietic stem/progenitor cells. Biotechnol Lett. 2016 Jan;38(1):175-81.

Cao L, Weng W, Chen X,, Ding Y, Yan Y, Li H, Zhao H, Shin JW, Wei J, Ji F, Su J. Development of degradable and bioactive composite as bone implants by incorporation of mesoporous bioglass into poly(L-lactide). Composites Part B-Enginerring. 2015 Aug;77:454-61.

Niu Y, Guo L, Liu J, Shen H, Su J, An X, Yu B, Wei J, Shin JW, Guo H, Ji F, He D. Bioactive and degradable scaffolds of the mesoporous bioglass and poly(L-lactide) composite for bone tissue regeneration. Journal of Materials Chemistry B. 2015 Apr;3(15):2962-70.

Shin JW, Kim HL, Kang YG, Park SH, Kim YM, Shin JW. Changes in Mitochondrial Properties during Stem Cell Differentiation induced by Mechanical Stretching. TERM. 2015 Feb;12(1):60-5.

Park SA. Lee JB. Kim YE. Kim JE. Lee JH, Shin JW, Kwon IK, Kim WD. Fabrication of biomimetic PCL scaffold using rapid prototyping for bone tissue engineering. Macromolecular Research. 2014 Aug;22(8):882-7.

Kang YG, Shin JW, Park SH, Oh MJ, Park HS, Shin JW, Kim SH. Effects of flow-induced shear stress on limbal epithelial stem cell growth and enrichment. PLoS One. 2014 Mar 21;9(3):e93023.

Park SH, Shin JW, Kang YG, Hyun JS, Oh MJ, Shin JW. Texture analyses show synergetic effects of biomechanical and biochemical stimulation on mesenchymal stem cell differentiation into early phase osteoblasts. Microsc Microanal. 2014 Feb;20(1):219-27.

Kang YG, Garcia MV, Marquez JC, Park SH, Oh MJ, Kim YM, Shin JW. Effects of Various Patterns of Intermittent Hydrostatic Pressure on the Osteogenic Differentiation of Mesenchymal Stem Cells. TERM. 2014;11(1):32-9.

Jeon KJ, Park SH, Shin JW, Kang YG, Hyun JS, Oh MJ, Kim SY, Shin JW. Combined effects of flow-induced shear stress and micropatterned surface morphology on neuronal differentiation of human mesenchymal stem cells. J Biosci Bioeng. 2014 Feb;117(2):242-7.

Kang YG, Kim JH, Shin JW, Baik JM, Choo HJ. Induction of bone ingrowth with a micropore bioabsorbable suture anchor in rotator cuff tear: an experimental study in a rabbit model. J Shoulder Elbow Surg. 2013 Nov;22(11):1558-66.

Park SH, Park SH, Park DS, Kang YG, Shin JW, Kim HK, Yoon TR, Shin JW. Characterization of a hybrid bone substitute composed of polylactic acid tetrapod chips and hydroxyapatite powder. TERM. 2013 Apr;10(2):71-6.

Jang MY, Chun SI, Mun CW, Hong KS, Shin JW. Evaluation of metabolomic changes as a biomarker of chondrogenic differentiation in 3D-cultured human mesenchymal stem cells using proton (1H) nuclear magnetic resonance spectroscopy. PLoS One. 2013 Oct 21;8(10):e78325.

Kim SY, Park SH, Shin JW, Kang YG, Jeon KJ, Hyun JS, Oh MJ, Shin JW. Mechanical stimulation and the presence of neighboring cells greatly affect migration of human mesenchymal stem cells. Biotechnol Lett. 2013 Nov;35(11):1817-22.

Park SH, Shin JW, Kim SH, Kang YG, Jeon KJ, Kim SY, Hyun JS, Shin JW. The Effects of Co-Culture and Physical Stimulation on the Differentiation of Mesenchymal Stem Cell into Vascular Lineage Cells. TERM. 2013 Feb;10(1):11-8.

Chun SI, Cho JH, Yang YI, Shin JW, Shin WJ, Mun CW. Proton (1H) nuclear magnetic resonance spectroscopy to define metabolomic changes as a biomarker of adipogenic differentiation in human mesenchymal stem cells. TERM. 2012 Apr;9(2):101-8.

Park SH, Park DS, Shin JW, Kang YG, Kim HK, Yoon TR, Shin JW. Scaffolds for bone tissue engineering fabricated from two different materials by the rapid prototyping technique: PCL versus PLGA. J Mater Sci Mater Med. 2012 Nov;23(11):2671-8.

Jeong JY, Park SH, Shin JW, Kang YG, Han KH, Shin JW. Effects of intermittent hydrostatic pressure magnitude on the chondrogenesis of MSCs without biochemical agents under 3D co-culture. J Mater Sci Mater Med. 2012 Nov;23(11):2773-81.

Kang YG, Jeon KJ, Park SH, Shin JW, Kim SY. Hyun JS, Shin WJ. Effects of Combinational Stimulation on the Differentiation of Mesenchymal Stem Cells into Osteoblast. TERM. 2012 Aug;9(2):73-80.

Kim HK, Park KS, Lee JS, Kim JH, Park DS, Shin JW, Yoon TR. Salicylideneamino-2-thiophenol enhances osteogenic differentiation through the activation of MAPK pathways in multipotent bone marrow stem cell. J Cell Biochem. 2012 Jun;113(6):1833-41.

Shin JW, Park SH, Kang YG, Shin JW. Potential of engineering methodologies for the application to pharmaceutical research. Archives of Pharmacal Research. 2012 Feb;35(2):299-309.

Heo SJ, Nerurkar NL, Baker BM, Shin JW, Elliott DM, Mauck RL. Fiber stretch and reorientation modulates mesenchymal stem cell morphology and fibrous gene expression on oriented nanofibrous microenvironments. Ann Biomed Eng. 2011 Sep;39(11):2780-90.

Kim DH, Heo SJ, Kim SH, Shin JW, Park SH, Shin JW. Shear stress magnitude is critical in regulating the differentiation of mesenchymal stem cells even with endothelial growth medium. Biotechnol Lett. 2011 Sep;33(12):2351-9.

Han JY, Shin JW, Park SH, Kim DH, Kim SH, Kang YG, Shin JW. Differentiation of stem cells based on cocktail medium and scaffold characteristics for osteochondral tisssue. TERM. 2011 Aug;8(2):59-65.

Park SH, Shin JW, Kim DH, Kim SH, Jeong OC, Jeong KK, Shin JW. Quantitative analyses of changes in intracellular calcium ion concentrations under flow-induced mechanical stimuli utilising a microchip. Micro & Nano Letters. 2011 May;6(5):296-300.

Jang JY, Lee SW, Park SH, Shin JW, Mun C, Kim SH, Kim DH, Shin JW. Combined effects of surface morphology and mechanical straining magnitudes on the differentiation of mesenchymal stem cells without using biochemical reagents. J Biomed Biotechnol. 2011 Feb;860652.

Kim SH, Park SH, Jun JW, Kim DH, Shin JW, Han JY, Kang YG, Shin JW. Hydrostatic pressure can control osteogenesis and osteoclastogenesis when stromal cells and osteoclast precursor cells are cocultured. TERM. 2010 Oct;7(4):388-94.

Jia J, Zhou H, Wei J, Jiang X, Hua H, Chen F, Wei S, Shin JW, Liu C. Development of magnesium calcium phosphate biocement for bone regeneration. J R Soc Interface. 2010 Aug 6;7(49):1171-80.

Jeong JY, Kim DH, Park SH, Shin JW, Han JY, Kang YG, Shin JW. Effects of PDMS surface patterns on differentiation and proliferation of MSCs under intermittent hydrostatic pressure. TERM. 2010 Aug;7(3):283-90.

Lee SW, Jang JY, Park SH, Kim DH, Shin JW, Kim SH, Shin JW. Study of mesenchymal stem cells co-cultured with endothelial cells under vascular fluidic environments. TERM. 2010 Jun;7(2):255-61.

Kim DH, Heo SJ, Shin JW, Mun CW. Preparation of thermosensitive gelatin-pluronic copolymer for cartilate tissue engineering. Macromolecular research. 2010 Apr;18(4):384-91.

Lee SW, Heo SJ, Jang JY, Jeong JY, Kim SH, Park SA, Jeon ES, Shin JW. Novel perfusion culture with 3-dimensional shape-controlled scaffolds for bone tissue engineering. TERM. 2010 Mar;7(1):9-15.

Wei J, Jia J, Wu F, Wei S, Zhou H, Zhang H, Shin JW, Liu C. Hierarchically microporous/macroporous scaffold of magnesium-calcium phosphate for bone tissue regeneration. Biomaterials. 2010 Feb;31(6):1260-9.

Wei J, Heo SJ, Liu C, Kim DH, Kim SE, Hyun YT, Shin JW, Shin JW. Preparation and characterization of bioactive calcium silicate and poly(epsilon-caprolactone) nanocomposite for bone tissue regeneration. J Biomed Mater Res A. 2009 Sep 1;90(3):702-12.

Kim DH, Kim SH, Heo SJ, Shin JW, Lee SW, Park SA, Shin JW. Enhanced differentiation of mesenchymal stem cells into NP-like cells via 3D co-culturing with mechanical stimulation. J Biosci Bioeng. 2009 Jul;108(1):63-7.

Kim DH, Heo SJ, Shin JW, Park SH, Shin JW. Effects of mechanical stimulation on chondrogenesis of mesenchymal stem cells via 3D co-culturing system. TERM. 2009 Jun;6:739-45.

Wei J, Wu X, Liu C, Jia J, Heo SJ, Kim SE, Hyun YT, Shin JW. Fabrication of bioactive scaffold of poly(e-Caprolactone) and nanofiber wollastonite composite. Journal of the American Ceramic Society. 2009 May;92(5):1017-23.

Heo SJ, Kim SE, Wei J, Kim DH, Hyun YT, Yun HS, Kim HK, Yoon TR, Kim SH, Park SA, Shin JW, Shin JW. In Vitro and animal study of novel nano-hydroxyapatite/poly(varepsilon-caprolactone) composite scaffolds fabricated by layer manufacturing process. Tissue Engineering Part A. 2009 May;15(5):977-89.

Shin JW, Lee YJ, Heo SJ, Park SA, Kim SH, Kim YJ, Kim DH, Shin JW. Manufacturing of multi-layered nanofibrous structures composed of polyurethane and poly(ethylene oxide) as potential blood vessel scaffolds. J Biomater Sci Polym Ed. 2009;20(5-6):757-71.

Heo SJ, Kim SE, Wei J, Hyun YT, Yun HS, Kim DH, Shin JW, Shin JW. Fabrication and characterization of novel nano- and micro-HA/PCL composite scaffolds using a modified rapid prototyping process. J Biomed Mater Res A. 2009 Apr;89(1):108-16.

Wei J, Chen F, Shin JW, Hong H, Dai C, Su J, Liu C. Preparation and characterization of bioactive mesoporous wollastonite - Polycaprolactone composite scaffold. Biomaterials. 2009 Feb;30(6):1080-8.

Yun HS, Kim SE, Hyun YT, Heo SJ, Shin JW. Hierarchically mesoporous-macroporous bioactive glasses scaffolds for bone tissue regeneration. J Biomed Mater Res B Appl Biomater. 2008 Nov;87(2):374-80.

Han SH, Kim YH, Park MS, Kim IA, Shin JW, Yang WI, Jee KS, Park KD, Ryu GH, Lee JW. Histological and biomechanical properties of regenerated articular cartilage using chondrogenic bone marrow stromal cells with a PLGA scaffold in vivo. J Biomed Mater Res A. 2008 Dec 15;87(4):850-61.

Kim JY, Park EK, Kim SY, Shin JW, Cho DW. Fabrication of SFF based three-dimensional scaffold using precise deposition system in tissue engineering. Journal of Micromechanics and Microengineering. 2008 May;18(5):1-7.

Kim YJ, Park S, Lee YJ, Shin JW, Kim DH, Heo SJ, Park KD, Shin JW. Effects of intermittent hydrostatic pressure on cell adhesive forces and other related parameters under various resting periods. J Biomed Mater Res B Appl Biomater. 2008 May;85(2):353-60.

Park KM, Bae JW, Joung YK, Shin JW, Park KD. Nanoaggregate of thermosensitive chitosan-Pluronic for sustained release of hydrophobic drug. Colloids Surf B Biointerfaces. 2008 May 1;63(1):1-6.

Yun HS, Kim SE, Hyun YT, Heo SJ, Shin JW. Three-dimensional mesoporous-giantporous inorganic/organic composite scaffolds for tissue engineering. Chemistry of Materials. 2007 Dec;19:6363-6.

Wei J, Heo SJ, Kim DH, Kim SE, Hyun YT, Shin JW. Comparison of physical, chemical and cellular responses to nano- and micro-sized calcium silicate/poly(epsilon-caprolactone) bioactive composites. J R Soc Interface. 2008 Jun 6;5(23):617-30.

Kim HJ, Bae JW, Kim CH, Lee JW, Shin JW, Park KD. Acellular matrix of bovine pericardium bound with L-arginine. Biomed Mater. 2007 Sep;2(3):S111-6.

Lee SG, An EY, Lee JB, Park JC, Shin JW, Kim JK. Enhanced cell affinity of poly(D,L-Lactic-co-glycolic acid) (50/50) by plasma treatment with β-(1→3) (1→6)-glucan. Surface & Coating technology. 2007 Feb;201:5128-31.

Kim SH, Choi YR, Park MS, Shin JW, Park KD, Kim SJ, Lee JW. ERK 1/2 activation in enhanced osteogenesis of human mesenchymal stem cells in poly(lactic-glycolic acid) by cyclic hydrostatic pressure. J Biomed Mater Res A. 2007 Mar 15;80(4):826-36.

Park SA, Kim IA, Lee YJ, Shin JW, Kim CR, Kim JK, Yang YI, Shin JW. Biological responses of ligament fibroblasts and gene expression profiling on micropatterned silicone substrates subjected to mechanical stimuli. J Biosci Bioeng. 2006 Nov;102(5):402-12.

Kim IA, Park SA, Kim YJ, Kim SH, Shin HJ, Lee YJ, Kang SG, Shin JW. Effects of mechanical stimuli and microfiber-based substrate on neurite outgrowth and guidance. J Biosci Bioeng. 2006 Feb;101(2):120-6.

Park HD, Bae JW, Park KD, Ooya T, Yui N, Jang JH, Han DK, Shin JW. Surface modification of polyurethane using sulfonated PEG grafted polyrotaxane for improved biocompatibility. Macromolecular Research. 2006 Jan;14:73-80.

Shin HJ, Lee CH, Cho IH, Kim YJ, Lee YJ, Kim IA, Park KD, Yui N, Shin JW. Electrospun PLGA nanofiber scaffolds for articular cartilage reconstruction: mechanical stability, degradation and cellular responses under mechanical stimulation in vitro. J Biomater Sci Polym Ed. 2006;17(1-2):103-19.

Lee CH, Shin HJ, Cho IH, Kang YM, Kim IA, Park KD, Shin JW. Nanofiber alignment and direction of mechanical strain affect the ECM production of human ACL fibroblast. Biomaterials. 2005 Apr;26(11):1261-70.

Jee KS, Bae JW. Park KD, Kim YH, Shin JW, Lee JW. Heparinized tissue matrices as novel biomaterials. ASBM6. 2005 Apr;288-289:450-6.

Park C, Kim YJ, Lee CS, An K, Shin HJ, Lee CH, Kim CH, Shin JW. An in vitro animal study of the biomechanical responses of anulus fibrosus with aging. Spine (Phila Pa 1976). 2005 May 15;30(10):E259-65.

Kim SJ, Shin JW, Lee CH, Shin HJ, Kim SH, Jeong JH, Lee JW. Biomechanical comparisons of three different tibial tunnel directions in posterior cruciate ligament reconstruction. Arthroscopy. 2005 Mar;21(3):286-93.

Kim SB, Kim YJ, Yoon TL, Park SA, Cho IH, Kim EJ, Kim IA, Shin JW. The characteristics of a hydroxyapatite-chitosan-PMMA bone cement. Biomaterials. 2004 Nov;25(26):5715-23.

Kim SH, Shin JW, Park SA, Kim YK, Park MS, Mok JM, Yang WI, Lee JW. Chemical, structural properties, and osteoconductive effectiveness of bone block derived from porcine cancellous bone. J Biomed Mater Res B Appl Biomater. 2004 Jan 15;68(1):69-74.

Park SA, Shin JW, Yang YI, Kim YK, Park KD, Lee JW, Jo IH, Kim YJ. In vitro study of osteogenic differentiation of bone marrow stromal cells on heat-treated porcine trabecular bone blocks. Biomaterials. 2004 Feb;25(3):527-35.

Lee SB, Shin JW, Wineman AS. An experimental study of nonlinear viscoelastic bushing model for axial mode. KSME. 2003 Sep;17:1324-31.

Lee JW, Kim YH, Park KD, Jee KS, Shin JW, Hahn SB. Importance of integrin beta1-mediated cell adhesion on biodegradable polymers under serum depletion in mesenchymal stem cells and chondrocytes. Biomaterials. 2004 May;25(10):1901-9.

Kim YJ, Shin JW, Park KD, Lee JW, Yui N, Park SA, Jee KS, Kim JK. A study of compatibility between cells and biopolymeric surfaces through quantitative measurements of adhesive forces. J Biomater Sci Polym Ed. 2003;14(12):1311-21.

Tack GR, Lee SY, Lee SJ, Jun BJ, Lim DH, Shin JW, Kim JK, Shin KC. Prediction of cement volume for vertebroplasty based on imaging and biomechanical results. KSME. 2001 Jul;15(7):1041-50.

Shin TJ. Vito RP. Johnson LW. McCarey BE. The distribution of tsrain in the human cornea. Journal of Biomechanics. 1997 May;30(5):497-503.

Cellular and Biomechanical Engineering Lab

In vitro cell experiments cannot yield true cell reponses without biomimetic environment.
Under this proposal, various engineering technologies along with biological knowledge are being developed and applied for the realization of the biomimetic environment.
Our laboratory develops novel methodologies based on engineering paradigms to translate research outcomes to clinical practice.

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